Evaluation of Antiulcer Activity of Ethanolic Extract of Daemia extensa (Jacq.) R. Br. Seed

Daemia extensa is a well-known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antioxidant, in-vitro antibacterial and antifungal activity. The aim was to search for anti-ulcer activity of ethanolic extract of Daemia extensa seed. Ethanolic extract of Daemia extensa seed was considered for its potential to protect gastric mucosa against ulcers induced by pylorus ligation and indomethacin induced methods. Ulcer index, free acidity, total acidity and percentage protection were used for evaluation of anti-ulcer activity. Pre-treatment with Daemia extensa seed extracts in dose of 400 mg/kg in both the models significantly diminished the ulcer index and the percentage protection of ulcer compared with control group (p<0.05). Based on the studies we concluded that the ethanolic extracts of Daemia extensa seeds might contain some active principles against ulcer healing properties.